Instituto Politécnico de Lisboa

Anita Gomes

Prof. Adjunto

Nota Biográfica

Academic degrees

  • 2002 Ph.D. Degree in Biology (Imperial College, University of London, UK) 
  • 1996 Degree in Biochemistry (Faculty of Sciences, University of Lisbon, Portugal)


Positions

  • 2008-Present Assistant Professor, Section of Biology, Department of Natural Sciences, ESTeSL, IPL
  • 2008-Present Senior Researcher, Project: Pre-/post- transcriptional mechanisms of functional differentiation of gd T lymphocytes, Institute of Molecular Medicine, Lisbon, Group leader: Bruno SilvaSantos Ph.D.
  • 2007-Present Postdoctoral Researcher, Project: Anti-tumor properties of gd T lymphocytes, Institute of Molecular Medicine, Lisbon, Group leader: Bruno SilvaSantos Ph.D.
  • 2004-2007  Assistant Professor, Section of Health Sciences, University of Madeira, Funchal, Portugal
  • 2003-2006 Postdoctoral Researcher, Project: Splicing factors expression profile during myogenesis, Institute of Molecular Medicine, Lisbon, Group leader: Maria Carmo-Fonseca MD., Ph.D.
  • 1998-2002  Postgraduate Researcher,Project: Membrane association and targeting of Rab GTPases), Imperial College, London, Group leader: Miguel Seabra, MD., Ph.D.
  • 1996-1998 Postgraduate Researcher, Project: CFTR immunolocalisation in biopsies from cystic fibrosis patients and corresponding cellular models, INSA, Lisbon, Group leader: Margarida Amaral Botelho, PhD


Working groups

  • Bruno Silva-Santos Lab – Instituto de Medicina Molecular, Universidade de Lisboa
  • Environmental Health RG – Escola Superior de Tecnologia de Saúde de Lisboa, Instituto Politécnico de Lisboa

 

Endereços Research Id/Orcid/Scopus

  • ResearcherID: C-3580-2014
  • Scopus Author ID: 7202386033
  • orcid id: 0000-0002-3348-0448

 

Scientific Production

Papers in international scientific periodicals with referees

  • Moutinho M, Nunes MJ, Gomes AQ, Gama MJ, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Rodrigues E. Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells. Mol Neurobiol. 2014 Aug 2. [Epub ahead of print].
  • Viegas C1, Dias R, Gomes AQ, Meneses M, Sabino R, Viegas S., Aspergillus flavus contamination in two Portuguese wastewater treatment plants. J Toxicol Environ Health A. 2014;77(14-16):796-805.
  • Viegas C, Faria T, Gomes AQ, Sabino R, Seco A, Viegas S. Fungal contamination in two Portuguese wastewater treatment plants. J Toxicol Environ Health A. 2014;77(1-3):90-102.
  • Viegas C, Gomes AQ, Abegão J, Sabino R, Graça T, Viegas S. Assessment of fungal contamination in waste sorting and incineration-case study in Portugal. J Toxicol Environ Health A. 2014;77(1-3):57-68.
  • Viegas C, Almeida-Silva M, Gomes AQ, Wolterbeek HT, Almeida SM. Fungal contamination assessment in Portuguese elderly care centers. J Toxicol Environ Health A. 2014;77(1-3):14-23.
  • Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B. (2013) Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gd T cell subsets. Nat Immunol. Sep 1. [Epub ahead of print].
  • Gomes AQ, Nolasco S, Soares H. Non-Coding RNAs: Multi-Tasking Molecules in the Cell. International Journal of Molecular Sciences. 2013; 14(8):16010-16039.
  • de Oliveira P, Gomes AQ, Pacheco TR, Vitorino de Almeida V, Saldanha C, Calado A. (2012) “Cell-specific regulation of acetylcholinesterase expression under inflammatory conditions. Clin Hemorheol Microcirc. 51(2):129-37. doi: 10.3233/CH-2011-1520
  • Barroso M, Rocha MS, Esse R, Gonçalves I Jr, Gomes AQ, Teerlink T, Jakobs C, Blom HJ, Loscalzo J, Rivera I, de Almeida IT, Castro R. (2012) Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells. Amino Acids. 42(5):1903-11. doi: 10.1007/s00726-011-0916-0.
  • Gomes AQ*, Martins DS* and Silva-Santos B (2010) “Targeting gd T-lymphocytes:from novel mechanistic insight to clinical application”. Cancer Research, 70(24):10024-7
  • Gomes AQ*, Correia DV*, Grosso AR, Lança T, Ferreira C, Lacerda JF, Barata JT, Silva MG, Silva-Santos B (2010) “Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells”. Haematologica Aug;95(8):1397-404.
  • Lanca T, Correia DV, Moita CF, Raquel H, Neves-Costa A, Ferreira C, Ramalho JS, Barata JT, Moita LF, Gomes AQ*, Silva-Santos B* (2010) “The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity.” Blood. Mar 25;115(12):2407-11.
  • Grosso AR, Gomes AQ, Barbosa-Morais NL, Caldeira S, Thorne NP, Grech G, von Lindern M, Carmo-Fonseca M (2008) “Tissue-specific splicing factor gene expression signatures.”Nuc. Ac. Res. 36(15):4823-32-
  • Gomes AQ, Correia DV e Silva Santos, B (2007) "Non-classical Major Histocompatibility Complex proteins as determinants of tumor immunosurveillance", EMBO Rep. (11):1024-30.
  • Pacheco TR, Moita LF, Gomes AQ, Hacohen N, Carmo-Fonseca M (2006) "RNAi Knockdown of hU2AF35 Impairs Cell Cycle Progression and Modulates Alternative Splicing of Cdc25 Transcripts". Mol. Biol. Cell (10):4187-99.
  • Pacheco TR, Gomes AQ, Barbosa-Morais NL, Benes V, Ansorge W, Wollerton M, Smith CW, Valcarcel J, Carmo-Fonseca M (2004) “Diversity of vertebrate splicing factor U2AF35: Identification of alternatively spliced U2AF1 mRNAs”. J Biol Chem. 279 (26): 27039-49.
  • Berciano MT, Villagra NT, Ojeda JL, Novascues J, Gomes A, Lafarga M, and Carmo-Fonseca M (2004) “Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus”. Hum Mol Genet. 13(8):829-38
  • Gomes AQ, Ali BR, Ramalho JS, Godfrey RS, Barral DC, Hume AN and Seabra MC (2003) “Membrane Targeting of Rab GTPases is influenced by the Prenylation Motif”. Mol. Biol. Cell. 14: 1882-1899.
  • Pereira-Leal JB, Gomes AQ and Seabra MC (2002) “Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase”. Methods  Mol. Biol. 189: 157-65.
  • Hume AN, Collinson LM, Rapak A, Gomes AQ, Hopkins CR and Seabra MC (2001) “Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes”. J. Cell Biol. 152: 795-808.
  • Bergo MO, Leung GK, Ambroziak P, Otto JC, Casey PJ, Gomes AQ, Seabra MC, Young SG (2001) “Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice”. J Biol Chem. 23;276(8):5841-5845.
  • Beck S, Penque D, Garcia S, Gomes A, Farinha C, Mata L, Gulbenkian S, Gil-Ferreira K, Duarte A, Pacheco P, Barrteto C, Lopes B, Cavaco  J, Lavinha J and Amaral MD (1999) “Cystic Fibrosis Patients with the 3272-26A®G Genotype Have Mild Disease, Leaky Alternative Splicing and CFTR Protein at the Membrane”. Human Mutation 14(2):133-44.

Communications in scientific meetings (oral or poster presentations)

A total of 50 communications in national and international meetings


Participation in research projects

  • Project European Research Council (ERC) STG-260352 "Differentiation of pro-inflammatory T cell subsets in vivo" - PI: Bruno Silva-Santos.
  • Project PTDC/SAU-NMC/110809/2009 - "Control of neuronal signaling pathways by CYP46A1, an enzyme involved in brain cholesterol turnover" - PI: Elsa Rodrigues.
  • Project PTDC/SAU-NEU/103639/2008 - "On the role of VIP receptors in hippocampal dependent cognition and synaptic plasticity: evaluation of the therapeutic potential of VPAC1 receptor antagonists to ameliorate the cognitive deficits in TLE" - PI: Diana Cunha-Reis.
  • Project PTDC/SAU-MII/104158/2008 - "Regulation of T cell differentiation and activation by CD27-CD70 receptor-ligand interactions in the thymus and in the periphery" - PI: Bruno Silva-Santos.
  • Project PTDC/BIA-BCM/71663/2006 - "Identificação de ligandos para receptores de linfócitos T gd: uma abordagem genómica e transcritómica" - PI: Bruno Silva-Santos.
  • Project PTDC/SAU-GMG/68714/2006 - "Estudo in vitro dos efeitos epigenéticos induzidos pela acumulação intracelular de S-adenosilhomocisteína na biodisponibilidade do óxido nítrico" - PI - Rita Castro.
  • Project MDA3662 (Muscle Distrophy Association, USA) - "Profiling alternative splicing in muscular dystrophies) - PI: Maria Carmo-Fonseca