Instituto Politécnico de Lisboa

Carina Ladeira

Adjunct Professor

Nota Biográfica

2010 - 2015: PhD in Biology, especialization Genetics by Faculty of Sciences, University of Lisbon. Research on Human Biomonitoring – Relation between biomarkers, individual susceptibility and nutrigenetics.

2007-2009: Master in Human Molecular Biology by Faculty of Sciences, University of Lisbon. Research on Genotoxicity Biomarkers and genetic polymorphisms in workers exposed to formaldehyde.

2002-2006: Graduation in Biomedical Sciences in Higher School of Health Technologies of Lisbon. 

Cargos

Since 2016: Adjunct Professor in Escola Superior de Tecnologia da Saúde de Lisboa, Scientific Area of Pathologic Anatomy, Cytology and Tanathology.

2006-2015: Assistant Lecturer in Escola Superior de Tecnologia da Saúde de Lisboa, Scientific Area of Pathologic Anatomy, Cytology and Tanathology.

2005-2007: Biomedical Scientist in Histocellular Pathology in Escola Superior de Tecnologia da Saúde de Lisboa.

Comissões

WORK GROUPS

Since 2018: Editorial Board of Mutation Research – Genetic Toxicology and Environmental Mutagenesis. (https://www.journals.elsevier.com/mutation-research-genetic-toxicology-and-environmental-mutagenesis/editorial-board)

Since 2018: Member of Editorial board of Toxics (http://oa.enpress-publisher.com/index.php/Toxi/index)

Since 2017: Member of Editorial Board of the Annals in Mutagenesis (http://austinpublishinggroup.com/mutagenesis/editorialBoard.php)

Since 2017: Member of Editorial board of Research and Review Archives http://escires.com/research-review-archives/editorial-board/

WORK GROUPS

2016-2020: HBM4EU - European Human Biomonitoring Initiative, European Commission - Research & Innovation (https://www.hbm4eu.eu/the-project/)

2016-2020: COST – European Cooperation in Science and Technology (supported by EU Framework programme). COST OC-2015-1-19739: The comet assay as a human biomonitoring tool. (http://www.cost.eu/COST_Actions/ca/CA15132)

2016-2018: Occupational exposure to particulate matter and fungi and potential health effects in bakers and cookies and biscuit production. ACT Project n. º 005DBB/12. 

2010-2013: Occupational exposure to cytostatic drugs: Characterization of cytostatic drugs in Portuguese hospitals. ACT Project n. º 036APJ/09.

2010-2011: Re-evaluation of a reported increased micronucleus frequency in lymphocytes of workers occupationaly exposed to formaldehyde. Collaboration with University of Ülm, Germany.

2007-2009: Genotoxicity Biomarkers and genetic polymorphisms in workers exposed to formaldehyde.

2006-2009: Occupational Exposure to Formaldehyde: contribution to the characterization of exposure and consequent health effects in workers of hospital services of Pathological Anatomy. ACT Project.

2005-2006: Risk Assessment of Chemicals in the Histopathology Laboratory of Anatomic Pathology Services. 

Áreas de Investigação

PUBLICATIONS

Gajski, G., Žegura, B., Ladeira, C., Novak, M., Sramkov, M., Pourrut, B., Del Bo, C., Milic, M., Gutzkwon, K., Costa, S., Dusinska, M., Brunborg, G., Collins, A. (2019). The comet assay in animal models: From bugs to whales – (Part 2 Vertebrates), Mutation Research/Reviews in Mutation Research (in press).

Azqueta, A., Langie, S., Boutet-Robine, E., Duthie, S., Ladeira, C., Møller, P., Collins, A., Godschalk, R., on behalf of Working Group 5 of the hCOMET project (CA15132) (2019). DNA repair as a human biomonitoring tool; comet assay approaches, Mutation Research/Reviews in Mutation Research 781 (2019) 71-87. DOI: 10.1016/j.mrrev.2019.03.002

Ladeira, C., Koppen, G., Scavone, F., Giovanelli, L. (2019). The comet assay for human biomonitoring: Effect of cryopreservation on DNA damage in different blood cell preparations Mutation Research/Genetic Toxicology and Environmental Mutagenesis (in pres). DOI: 10.1016/j.mrgentox.2019.02.002

Gajski, G., Žegura, B., Ladeira, C., Pourrut, B., Novak, M., Sramkov, M., Milic, M., Gutzkwon, K., Costa, S., Dusinska, M., Brunborg, G., Collins, A. (2019). The comet assay in animal models: From bugs to whales – (Part 1 Invertebrates), Mutation Research/Reviews in Mutation Research 779: 82-113. DOI: 10.1016/j.mrrev.2019.02.003

Ramos C., Ladeira C., Zeferino S., Dias A., Faria I., Cristovam E., Gomes M. and Ribeiro E. (2019). Cytotoxic and genotoxic effects of environmental relevant concentrations of Bisphenol A and interactions with Doxorubicin. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 838: 28-36, DOI: 10.1016/j.mrgentox.2018.11.009

Lisboa, R., Mascarenhas, P., Gil, F., Ruano, F., Ladeira, C., Morais, Z. (2018). Preliminary studies on the lifecycle of Catostylus tagi: differentiation between female and male at morphological level Translational Research and Innovation in Human and Health Science, Annals of Medicine, 50:sup1, S10-S170, DOI: 10.1080/07853890.2018.1427445

Viegas, S., Ladeira, C., Costa-Veiga, A., Perelman, J., Gajski, G. (2017). Forgotten public health impacts of cancer – an overview. Arh Hig Rada Toksikol 2017; 68:287-297. DOI: 10.1515/aiht-2017-68-3005.

Gajski, G., Ladeira, C., Gerić, M., Garaj-Vrhovac, V., Viegas, S. (2017). Genotoxicity assessment of a selected cytostatic drug mixture in human lymphocytes: A study based on concentrations relevant for occupational exposure. Environ Res 161: 26-34. doi: 10.1016/j.envres.2017.10.044.

Oliveira, F., Carmona, A., Ladeira, C. (2017). Genotoxicity assessment data for exfoliated buccal cells exposed to mobile phone radiation. Data in Brief 15: 344-347.

Ladeira, C., Frazzoli, C., Orisakwe, O. (2017). Engaging One Health for Non-Communicable Diseases in Africa: Perspective for Mycotoxins. Frontiers in Public Health 5: 1-15. doi: 10.3389/fpubh.2017.00266

Ladeira, C., Smajdova, L. (2017). The use of genotoxicity biomarkers in molecular epidemiology:

Applications in environmental, occupational and dietary studies. AIMS Genetics, 4 (3): 166-191.

Ribeiro, E., Ladeira, C., Viegas, S. (2017). Occupational Exposure to Bisphenol A (BPA): A Reality That Still Needs to Be Unveiled Toxics 5, 5, 22; doi: 10.3390/toxics5030022.

Oliveira, F., Carmona, A., Ladeira, C. (2017). Is mobile phone radiation genotoxic? An analysis of micronucleus frequency in exfoliated buccal cells. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 822: 41–46.

Ribeiro, E., Ladeira, C., Viegas, S. 2017. EDCs mixtures: a stealthy hazard for human health? Toxics 5, 5; doi:10.3390/toxics5010005.

Ladeira, C., Carolino, E., Gomes, M.C., Brito, M. (2017). Role of macronutrients and micronutrients in DNA damage: results from a food frequency questionnaire. Nutrition and Metabolic Insights 1-8. DOI: 10 1178638816684666.

Ladeira, C., Viegas, S. (2016). Human biomonitoring - An overview on biomarkers and their application in Occupational and Environmental Health. Biomonitoring 3: 15-24.

Ribeiro, E., Ladeira, C., Viegas, S. (2016). EDCs mixture effects in human cell lines. Toxicology Letters 258:S320.

Ladeira, C., Pádua, Veiga, L., Viegas, S., Carolino, E., Gomes, MC., Brito, M. (2016).

Influence of Serum Levels of Vitamins A, D, and E as well as Vitamin D Receptor Polymorphisms on Micronucleus Frequencies and Other Biomarkers of Genotoxicity in Workers Exposed to Formaldehyde. J Nutrigenet Nutrigenomics 8: 205–214. DOI: 10.1159/000444486.

Ladeira, C., Viegas, S., Pádua, M., Gomes, M.C., Carolino, E., Gomes, MC., Brito, M. (2015). Relation between DNA damage measured by comet assay and OGG1 Ser326Cys in antineoplastic drugs biomonitoring. AIMS Genetics Epidemiology 2 (3):204-218. DOI: 10.3934/genet.2015.3.204.

S. Viegas, C. Ladeira, M. Pádua, M. Gomes. Antineoplastic occupational exposure: Is exposure to mixtures being considered in the risk assessment process? Toxicology Letters. Vol. 238 (2S) S1 – S420. Pag. S92. ISSN 0378 – 4274.

Ladeira, C., Viegas, S., Carolino, E., Gomes, M.C., Brito, M. (2015). Micronutrients intake associated with DNA damage assessed by in a human biomonitoring study, ICAW 2015 - 11th International Comet Assay Workshop. DOI: 10.3389/conf.fgene.2015.01.00012.

Ladeira, C., Viegas, S., Carolino, E., Gomes, M.C., Brito, M. (2015). Correlation between the genotoxicity endpoints measured by two different genotoxicity assays: comet assay and CBMN assay, ICAW 2015 - 11th International Comet Assay Workshop. DOI: 10.3389/conf.fgene.2015.01.00027

Ladeira, C., Viegas, S., Pádua, M., Carolino, E., Gomes, M.C., Brito, M. (2015). Comet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugs, ICAW 2015 - 11th International Comet Assay Workshop, DOI: 10.3389/conf.fgene.2015.01.00019

Ladeira, C. Human biomonitoring: biomarkers, susceptibility, and nutrigenetics. 2015. Lynch S (ed). Germany: LAP Lambert Academic Publishing. ISBN: 978-3-659-68938-3. (Book).

Ladeira, C. & Viegas, S. Formaldehyde: exposure and genotoxicity assessments and potential health effects. 2015. Patton A (ed). Formaldehyde: synthesis, applications, and potential health effects. Chapter 3. New York: Nova Science Publishers. ISBN: 978-63482-426-2 (eBook).

Ladeira, C. Mycotoxins – Methodologies. 2015. C. Viegas, S. Viegas (eds). Environmental Mycology in Public Health: An Overview on Fungi and Mycotoxins for Risk Assessment and Management. London: Elsevier. ISBN: 978-0-12-411471-5

Ladeira, C., Gomes, M.C., Brito, M. 2014. Human Nutrition, DNA damage and Cancer: a review. N. Tomlekova, I. Kozgar and R. Wani (eds). Mutagenesis: exploring novel genes and pathways. DOI: 10.3920/978-90-8686-787-5-3. Wageningen Academic Publishers. ISBN: 978-90-8686-244-3.

Ladeira, C., Viegas, S., Pádua, M., Gomes, M.C., Carolino, E., Gomes, MC., Brito, M. Assessment of genotoxic effects in nurses handling cytostatic drugs. (2014). Journal of Toxicology and Environmental Health, Part A: Current Issues, 77:14-16, 879-887. DOI: 10.1080/15287394.2014.910158.

Ladeira, C. Viegas, S., Carolino, E., Gomes, MC., Brito, M. (2013). The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde. Environmental Molecular Mutagenesis 01/2013; DOI:10.1002/em.21755.

Viegas, S., Ladeira, C., Gomes, M., Prista, J., Brito, M., Exposure and genotoxicity assessment methodologies – The case of formaldehyde occupational exposure, Current Analytical Chemistry 9 (6) (2013) 476 - 484.

Ladeira, C., Viegas, S., Carolino, E., Gomes, M.C., Brito, M. (2012). Genotoxicity biomarkers: application in histopathology laboratories. Biomarker, Chapter 7. Croatia: Intech. P. 133-154. ISBN 979-953-307-612-5.

Viegas, S., Ladeira C., Gomes, M., Brito, M., Genotoxic effects of occupational exposure to formaldehyde, Carcinogen, Chapter 2. Croatia: Intech. ISBN 979-953-307-466-4.

Ladeira, C., Viegas, S., Carolino, E., Gomes, M., Prista, J., Gomes, M.C., Brito, M. Exposição Ocupacional a Formaldeído: Avaliação da Exposição e Efeitos Genotóxicos, Revista Saúde & Tecnologia 7 (2012) 18-27.

Speit, G., Ladeira, C., Linsenmeyer, R., Schütz, P., Högel, J., Re-evaluation of a reported increased micronucleus frequency in lymphocytes of workers occupationally exposed to formaldehyde, Mutation Research 744 (2012) 161-166.

Ladeira, C. (2012). Formalina ou formol? Qual o termo mais correcto. Mícron 16, 14.

Duarte, P., Direito I., Ladeira C. Descalcificação em micro-ondas com ácido nítrico a 5% e RDO. Mícron 16 (2012) 16-21.

Ladeira, C., Viegas, S., Carolino, E., Gomes, M.C., Brito, M. Genotoxicity biomarkers in occupational exposure to formaldehyde – the case of histopathology laboratories, Mutation Research 721 (2011) 15–20.

Viegas, S., Ladeira, C., Nunes, C., Malta-Vacas, J., Gomes, M., Brito, M., Mendonça, P., Prista, J., Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production. Journal of Occupational Medicine and Toxicology 2010, 5: 25, http://www.occup-med.com/contents/5/1/25

Gasalho, A., Silva, J., Mendes, M., Ladeira, C., A influência da fixação na demonstração do glicogénio. Mícron 15 (2011) 5-9.

Meneses, R., Kakoo, S., Damião, V., Carolino, E., Ladeira, C., Influência da longevidade da solução de Verhöeff na intensidade/especificidade das fibras elásticas, em material biológico de origem suína. Mícron 15 (2011) 10-14.

Ladeira, C., Parceria da APTAP com a RETS. Associação Portuguesa de Técnicos de Anatomia Patológica (2011). Livro 25 Anos de Evolução Técnico-Científica. Página 74.

Ladeira, C., Gomes, M.C., Brito, M. “Interaction of formaldehyde and tobacco smoking in the frequency of micronucleus and the XRCC3 Thr241Met polymorphism”, 8th International Symposium on Biological Monitoring in Occupational and Environmental Health, 6 -8 September, Espoo, Finland. ISBN 978-952-261-008-9

Ladeira, C., Viegas, S., Nunes, C., Malta-Vacs, J., Gomes, M., Mendonça, P., Prista, J., Gomes, M.C., Brito, M. “Occupational exposure to formaldehyde: effects of years of exposure in the frequency of micronucleus”, 8th International Symposium on Biological Monitoring in Occupational and Environmental Health, 6 -8 September, Espoo, Finland. ISBN 978-952-261-008-9.

Viegas, S., Ladeira, C., Nunes, C., Gomes, M., Brito, M., Prista, J. “Occupational exposure to formaldehyde in anatomy pathology laboratories: differences between exposure groups”, 8th International Symposium on Biological Monitoring in Occupational and Environmental Health, 6 -8 September, Espoo, Finland. ISBN 978-952-261-008-9.

Viegas, S., Ladeira, C., Malta-Vacas, J., Brito, M., Prista, J. “Cancer risk assessment in formaldehyde occupational exposure”, 8th International Symposium on Biological Monitoring in Occupational and Environmental Health, 6 -8 September, Espoo, Finland. ISBN 978-952-261-008-9

Ladeira, C., Viegas, S., Carolino, E., Gomes, M.C., Brito, M., “Effects of the interaction of tobacco smoke and alcohol consumption on buccal micronucleus in workers occupationally exposed to formaldehyde”, Toxicology Letters 196S (2010), S43.

Viegas, S., Ladeira, C., Nunes, C., Malta-Vacas, J., Gomes, M., Brito, M., Mendonça, P., Prista, J., Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production”, Toxicology Letters 196S (2010), S37.

Ladeira, C., Viegas, Prista, J., Gomes, M.C., Brito, M., “Effects of age and gender on peripheral lymphocytes micronucleus”, European Journal of Cancer 5 (8), June 2010, ISSN 1359-6349.

Ladeira, C., Gomes, M.C., Brito, M., “ADH3 Ile 349 Val polymorphism influence on genotoxicity biomarkers frequency in workers occupationally exposed to formaldehyde”, European Journal of Cancer 5 (8), June 2010, ISSN 1359-6349.

Ladeira, C., Gomes, M.C., Brito, M. “Lifestyle factors influence in the frequency of buccal micronucleus European Journal of Cancer 5 (8), June 2010, ISSN 1359-6349.

Ladeira, C., Gomes, M.C., Brito, M. “XRCC3 Thr 241 Met polymorphism influence on genotoxicity biomarkers frequency in workers occupationally exposed to formaldehyde”, European Journal of Cancer 5 (8), June 2010, ISSN 1359-6349.

- Ladeira, C., Viegas, S., Prista, J., Malta-Vacas, J., Gomes, M., Mendonça, P., Brito, M. (2009). Micronuclei in peripheral blood lymphocytes in formaldehyde occupationally exposed workers, Toxicology Letters, 189S, pp. S238.

- Ladeira, C., Mendonça, P., Albuquerque, M. & Antunes, L. (2008). The teaching of citology in the university degree of pathological anatomy: the experience of the portuguese school. Medicine Clinical Chemistry, 46, Special Suppl, pp S1-S859.

- Ferro, A., Ladeira, C. & Matos, M. (2008). Spicy the school curriculum: testing the model in SPICES Technologies Professor of Health, 97, Series III, January-April, pp.65-72.

- Ferro, A., Ladeira, C. & Matos, M. (2008). Diagnosis, prognosis and therapy of neoplasms of the Breast: Role of Pathologic Anatomy. TDTOnline Magazine. May / June.

- Ferro, A., Ladeira, C., Ribeiro, C., Viegas, C. & Figueira, E. (2007). Perception of Pathological Anatomy of technicians face the danger of the chemical used in laboratories Histopathology. Micron, 14, 28 – 32.

- Ladeira, C., Ribeiro, C., Figueira, E. & Marques, J. (2007). Grocott’s Alternative Protocol technique. Micron, 14, 40 – 45.

- Ferro, A., Ladeira, C., Ribeiro, C., Viegas, C., Figueira, E., Albuquerque, P. & Quintino, F. (2007). Suitability of an Instrument for Qualitative Assessment of Risk in chemical pathology. Universidade do Minho: School of Engineering. Proceedings of the International Symposium on Occupational Safety and Health Guimarães.