Instituto Politécnico de Lisboa

Helena Soares

Prof. Coordenador

Nota Biográfica

  • Doutoramento em Ciências Biomédicas, Especialidade Biologia Molecular, disciplina afim Genética Molecular pelo Instituto de Ciências Biomédicas "Abel Salazar" da Universidade do Porto, 1992.
  • Licenciatura em Biologia (ramo científico), pela Faculdade de Ciências da Universidade de Lisboa, 1986.
  • Academic Qualifications

    • PhD degree in Biomedical Sciences, speciality-Molecular Biology and Molecular Genetics, Instituto de Ciências Biomédicas "Abel Salazar" University of  Porto, 1992.
    • Degree in Biology (Scientific area), Faculdade de Ciências, University of Lisboa, 1986.

Cargos

RELEVANTES:

Desde Novembro de 2017- Presidente do Conselho de Representantes  e do Conselho de Ética da Escola Superior da Tecnologia de Sáude de Lisboa

Fevereiro de 2005 a Fevereiro 2009-Presidente do Conselho Científico da Escola Superior da Tecnologia de Sáude de Lisboa.

Novembro de 2003- Novembro 2005-Directora do Departamento das Ciências Naturais e Exactas da Escola Superior de Tecnologia da Sáude de Lisboa.

Áreas de Investigação

Os microtúbulos são polímeros polarizados de heterodímeros de α/β-tubulina que participam numa vasta variedade de funções celulares que vão da divisão celular, transporte intracelular, sinalização à locomoção. Atualmente, estamos a investigar qual o papel do citoesqueleto de microtúbulos de parasitas pertencentes ao filo dos Apicomplexa na invasão celular do hospedeiro. Temos também como objetivo mostrar que o H2O2 possui um papel de regulador no centrossoma estando envolvido na regulação de processos celulares tão diversos como a dinâmica do citoesqueleto de microtúbulos e a biologia dos cílios, que têm impacto em patologias humanas, e.g. as doenças neurodegenerativas e envelhecimento. Neste contexto estamos a estudar a proteína TBCC-domain containing 1 (TBCCD1), que recentemente descrevemos como sendo uma possível proteína reguladora do posicionamento núcleo-centrossoma e, consequentemente, da organização interna da célula.

Research interests: Microtubules (Mts) are polarized polymers of α/β-tubulin heterodimers participating in a wide range of cell functions, e.g. cell division, cell signaling, intracellular transport and locomotion. 
We are investigating the critical role of the cross-talk between the microtubule cytoskeleton of the Apicomplexa protozoan parasites Besnoitia besnoiti and Toxoplasma gondii, and the microtubule cytoskeleton of the host cell in the event of host cell invasion. We are also interested in uncovering a role for H2O2 as a key centrosomal regulatory molecule, involved in the regulation of a variety of cellular processes from microtubule cytoskeleton dynamics to cilia biology with impact in human diseases e.g neurodegenerative diseases and aging. In this context we are studying the TBCC-domain containing 1 (TBCCD1), which we described as being a putative key regulator of nucleus-centrosome positioning and, consequently, of internal cell organization.

Local de investigação/Working group/s:

ORCID ID:  0000-0001-6180-7041

SCOPUS ID: 55932139400

Research ID: G-3065-2010

- Publicações relevantes/Selected publications:

Seixas C, Gonçalves J, Melo LV, Soares H. Tetrahymena Cilia Cap is Built in a Multi-step Process: A Study by Atomic Force Microscopy. Protist. 2017 Dec;168(6):697-717. doi: 10.1016/j.protis.2017.10.001.

Cardoso R, Soares H, Hemphill A, Leitão A. Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology. 2016Jul;143(8):957-70. doi: 10.1017/S0031182016000524.

Cardoso, R., Nolasco, S., Gonçalves, J., Cortes, H.C., Leitão, A., and Soares, H. 2014. Besnoitia besnoiti and Toxoplasma gondii: two apicomplexan strategies to manipulate the host cell centrosome and Golgi apparatus. Parasitology 141(11): 1436-54.

Marinho H.S., Real, C., Cyrne, L., Soares, H., Antunes, F. (2014) Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol. 2, 535-562. doi: 10.1016/j.redox.2014.02.006. Top 1% ISI paper

Soares H, Marinho HS, Real C, Antunes F. (2014) Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr 9(1):371. (This paper was listed as a key scientific article in the edition of Global Medical Discovery Series: http://globalmedicaldiscovery.com/key-scientific-articles/cellular-polar...

Anita Quintal Gomes, Sofia Nolasco, Helena Soares (2013) Non-Coding RNAs: Multi-Tasking Molecules in the Cell. Int. J. Mol. Sci., 14, 16010-16039; doi:10.3390/ijms140816010; (Recommended in F1000; http://f1000.com/prime/718082667)

Carranza G, Castaño R, Fanarraga ML, Villegas JC, Gonçalves J, Soares H, Avila J, Marenchino M, Campos-Olivas R, Montoya G, Zabala JC. (2013) Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics. Cell Mol Life Sci. 70 :357-71. (This paper was listed as a key scientific article in the edition of Global Medical Discovery Series; http://globalmedicaldiscovery.com/key-scientific-articles/autoinhibition....)

Nolasco S, Bellido J, Gonçalves J, Tavares A, Zabala JC, Soares H.(2012) The expression of tubulin cofactor A (TBCA) is regulated by a noncoding antisense Tbca RNA during testis maturation. PLoS One. 7(8):e42536. doi:10.1371/journal.pone.0042536.

Tavares A, Gonçalves J, Florindo C, Tavares AA, Soares H. (2012) Mob1: defining cell polarity for proper cell division. J Cell Sci. 125:516-27. (Paper chosen by Centro de Química e Bioquímica scientific advisory board as being the best CQB paper of 2012. Before this paper had been tagged as being of special interest to the drug development sector and was listed as a key scientific article in the edition of Global Medical Discovery Series: http://globalmedicaldiscovery.com/key-scientific-articles/mob1-defining-....)

Seixas, AC., Cruto, T., Gaertig, J. and Soares, H. (2010) CCTα and CCTd chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena PLoS OneE 5(5): e10704. doi:10.1371/journal.pone.0010704.

Gonçalves, J, Nolasco,S, Nascimento, R, Lopez Fanarraga, M, Zabala, JC and Soares, H. (2010) TBCCD1, a new centrosomal protein is required for centrosome and Golgi apparatus positioning. EMBO Reports 11:194 – 200

Ramalho, R.R.,. Soares, H and Melo, L.V. (2007). Microtubule behavior under strong electromagnetic fields. Mat. Sci. Eng. C. 27:1207–1210.

Reis Y, Cortes H, Viseu Melo L, Fazendeiro I, Leitao A, Soares H. (2006) Microtubule cytoskeleton behavior in the initial steps of host cell invasion by Besnoitia besnoiti. FEBS Lett.580:4673-4682.

Nolasco, S., Bellido, J., Gonçalves, J., Zabala, JC and Soares, H. (2005) TBCA gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death.” FEBS Lett.579:3515-3524.

Casalou, C., Viseu Melo, L., Nolasco, S., Cecília Seixas, A., Brogueira, P. and Soares, H. (2003) "Subunits of the chaperonin CCT are associated with Tetrahymena microtubule structures and are involved in cilia biogenesis". Exp.Cell Res. 290:303-321.

Soares, H., Cyrne, L., Casalou, Ehmann, B. e Rodrigues-Pousada, C. (1997) "The third member of Tetrahymena CCT-subunit gene family, TpCCTα, encodes a component of the hetero-oligomeric chaperonin complex." Biochem J., 326: 21-29

Dujon, B., (...) Soares, H. (...) e Mewes, H.W. (Num total de 107 autores) (1994) "Complete DNA sequence of yeast chromosome XI" Nature, 369:371

 

Grau Académico

Doutor/PhD

Departamento

Área Científica

Email de Contacto

helena.soares@estesl.ipl.pt

Outros Contactos

Gabinete 2.11